Mitsui Lab




業 績 Achievements


  *, corresponding author.


  1. Hirota, Y., Otsuki, C., Kamura, E., *Mitsui, S., Intracerebral delivery of an OTR antagonist and subsequent behavioral testing in prairie voles. Methods in Molecular Biology, in press.
  2. Hirota, Y., Arai, A., Young, L. J., Osako, Y., Yuri, K., *Mitsui, S., Oxytocin receptor antagonist reverses the blunting effect of pair bonding on fear learning in monogamous prairie voles. Hormones and Behavior 120, 104685.
  3. Arai, A., Hirota, Y., *Mitsui, S., Pair bond formation by monogamous prairie voles in novel environments. Kitakanto Medical Journal 69, 129-133, 2019.
  4. Hidaka, C., Kashio, T., Uchigaki, D., *Mitsui, S., Vulnerability or resilience of motopsin knockout mice to maternal separation stress depending on adulthood behaviors. Neuropsychiatric Diseases and Treatment 14, 2255¬–2268, 2018.
  5. Tsuchiya, K., Mitsui, S., Fukuyama, R., Yamaya, N., Fujita, T., Shimoda, K., *Tozato, F., An acute bout of housework activities has beneficial effecs on executive function. Neuropsychiatric Diseases and Treatment 14, 61-72, 2018.
  6. *Osako, Y., Nobuhara, R., Arai, Y. P., Young, L. J., Nishihara, M., Mitsui, S., Yuri, K., Partner loss in monogamous rodents: Modulation of pain and emotional behavior in male prairie voles. Psychosomatic Medicine 80, 62-68, 2018. doi: 10.1097/PSY. 0000000000000524
  7. Arai, A., Hirota, Y., Miyase, N., Miyata, S., Young, L. J., Osako, Y., Yuri, K., Mitsui, S., A single prolonged stress paradigm produces enduring impairments in social bonding in monogamous prairie voles. Behavioural Brain Research 315, 83-93, 2016. doi:10.1016/j.bbr.2016.08.022
  8. Hidaka, C., *Mitsui, S., N-glycosylation modulates filopodia-like protrusions induced by sez-6 through regulating the distribution of this protein on the cell surface. Biochemical and Biophysical Research Communications 462, 346–351, 2015.
  9. Nakamura, K., Takabe, A., Shimizu, F., Takahashi, M., Matsuo, O., *Mitsui, S., Tissue plasminogen activator modulates emotion in a social context. Behavioural Brain Research 281, 24–31, 2015. doi:
  10. *Mistui, S., Osako, Y., Yuri, K., The mental retardation-related protease, motopsin (prss12), binds to the BRICHOS domain of the integral membrane protein 2a. Cell Biology International 38, 117–¬123, 2014. doi: 10.1002/cbin.10164
  11. *Mitsui, S., Hidaka, C., Furihata, M., Osako, Y., Yuri, K., A mental retardation gene, motopsin/prss12, modulates cell morphology by interaction with seizure-related gene-6. Biochemical Biophysical Research Communications 436, 638–644, 2013.
  12. Higashi, K., Hasegawa, M., Yokoyama, C., Tachibana, T., Mitsui, S., Saito, K., Dermokine-β impairs ERK signaling through direct binding to GRP78. FEBS Letters 586, 2300-2305, 2012.
  13. Osaki, G., Mitsui, S., Yuri, K., The distribution of the seizure-related gene 6 (Sez-6) protein during postnatal development of the mouse forebrain suggests multiple functions for this protein: An analysis using a new antibody. Brain Research 1386, 58-69, 2011. doi:10.1016/j.brainres.2011.02.025
  14. Mitsui, S., Osako, Y., Yokoi, Y., Dang, M. T., Yuri, K., Li Y., Yamaguchi, N., A mental retardation gene, motopsin/neurotrypsin/prss12, modulates hippocampal function and social interaction. European Journal of Neuroscience 30, 2368-2378, 2009. DOI: 10.1111/j.1460-9568.2009.07029.x
  15. Mitsui, S., Watanabe, Y, Yamaguchi, T., Yamaguchi, N., Mosaic serine proteases in the mammalian central nervous system.  Frontier in Biosciences 13, 1991-2000, 2008.
  16. Yoki, F., Dang, T. Mai, Mitsui, S., Li, J., Li, Y., Motor deficits and hyperactivity in cerebral cortex-specific Dyt1 conditional knockout mice. Journal of Biochemistry, 143, 39-47, 2008.
  17. Mitsui, S., Yamaguchi, N., Osako, Y., Yuri, K., Enzymatic properties and localization of motopsin (PRSS12), a protease whose absence causes mental retardation. Brain Research 1136, 1-12, 2007.
  18. Mitsui, S., Nakamura, T., Okui, A., Kominami, K., Uemura, H., Yamaguchi, N., Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin.  FEBS Journal 273, 3678-3686, 2006
  19. Numajiri, T., Mitsui, S., Hisa, Y., Ishida, T., Nishino, K., Yamaguchi, N., The expression of a motoneuron-specific serine protease, motopsin (PRSS12), after facial nerve axotomy in mice.  Journal of Plastic, Reconstructive & Aesthetic Surgery 59, 393-397, 2006
  20. Mitsui, S., Okui, A., Kominami, K., Konishi, E., Uemura, H., and Yamaguchi, N., A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells.  FEBS Journal 272, 4911-4923, 2005
  21. Yokoi, F., Dang, M. T., Mitsui, S., and Li, Y., Exclusive paternal expression and novel alternatively spliced variants of e-sarcoglycan mRNA in mouse brain.  FEBS Letters 579, 4822-4828, 2005
  22. Watanabe, Y., Okui, A., Mitsui, S., Kawarabuki, K., Yamaguch, T., Uemura, H., and Yamaguchi N., Molecular cloning and tissue-specific expression analysis of mouse spinesin, a type II transmembrane serine protease 5.  Biochemical Biophysical Research Communications 324, 333-340, 2004
  23. Higashi, K., Inagaki, Y., Suzuki, N., Mitsui, S., Mauviel, A., Kaneko, H., Nakatsuka, I., Y-box-binding Protein YB-1 Mediates Transcriptional Repression of Human α2(I) Collagen Gene Expression by Interferon-γ Journal of Biological Chemistry 278, 5156-5162, 2003.
  24. Nakamura T, Mitsui, S., Okui A, Miki T, Yamaguchi N: Molecular Cloning and Expression of a Variant Form of Hippostasin/KLK11in Prostate. The Prostate 54, 299-305, 2003.
  25. Mitsui, S., Okui A, Uemura H, Mizuno T, Yamada T, Yamamura T, Yamaguchi N: Decreased cerebrospinal fluid levels of neurosin (KLK6), an ageing-related protease, as a possible new risk factor for Alzheimer’s disease. Annals of NewYork Academy of Science 977: 216-223, 2002.
  26. Sogame Y, Kataoka K, Kato M, Sakagami J, Osawa S, Takatera A, Mitsuyoshi M, Usui N, Mitsui, S., Yamaguchi N: Molecular cloning and characterization of chymopasin, a novel serine protease from rat pancreas. Pancreas 25: 378-386, 2002.
  27. Yamaguchi N, Okui A, Yamada T, Nakazato H, Mitsui, S., Spinesin/TMPRSS5, a novel transmembrane serine protease, cloned from human spinal cord. Journal of Biological Chemistry 277, 6806-6812, 2002.
  28. Diamandis E P, Okui A, Mitsui, S., Luo L Y, Soosaipillai A, Grass L, Nakamura T, Howarth D J, Yamaguchi N., Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma. Cancer Research 62, 295-300, 2002.
  29. Nakamura T, Mitsui, S., Okui A, Kominami K, Nomoto T, Ukimura O, Kawauchi A, Miki T, Yamaguchi N., Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines. The Prostate 49, 72-78, 2001.
  30. Okui A, Kominami K, Uemura H, Mitsui, S., Yamaguchi N., Characterization of a brain-related serine protease, neurosin (human kallikrein 6) in human cerebrospinal fluid. NeuroReport 12, 1345-1350, 2001.
  31. Mitsui, S., Ohuchi A, Adachi-Yamada T, Hotta M, Tsuboi R, Ogawa H: Cyclin-dependent kinase inhibitors, p21waf1/cip1 and p27kip1, are expressed site- and hair cycle-dependently in rat hair follicles. Journal of Dermatological Science 25, 164-169, 2001.
  32. Lee, Y.-R., Yamazaki, M., Mitsui, S., Tsuboi, R., and Ogawa, H: Hepatocyte growth factor (HGF) activator expressed in hair follicles is involved in in vitro HGF-dependent hair follicle elongation. Journal of Dermatological Science 25, 165-163, 2001.
  33. Mitsui, S., Oku, A, Kominami K, Uemura H, Yamaguchi N: cDNA cloning and tissue-specific splicing variants of mouse hippostasin/TLSP (PRSS20). Biochimica at Biophysica Acta 1494, 206-210, 2000.
  34. Mitsui, S., Yamada T, Okui A, Kominami K, Uemura H, Yamaguchi N., A novel isoform of a kallikrein-like protease, TLSP/Hippostasin (PRSS20), is expressed in the human brain and prostate. Biochemical Biophysical Research Communications 272, 205-211, 2000.
  35. Ogawa K, Yamada T, Tsujioka Y, Taguchi J, Takahashi M, Tsuboi Y, Fujino Y, Nakajima M, Yamamoto T, Akatsu H, Mitsui, S., Yamaguchi N., Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's and Parkinson's disease. Psychiatry and Clinical Neuroscience 54, 419-426, 2000.
  36. Iijima, N., Tanaka, M., Mitsui, S., Yamamura, Y., Yamaguchi, N., Ibata, Y.; Expression of a novel serine protease (motopsin PRSS12) mRNA in the mouse brain. :in situ hybridization histochemical study.  Molecular Brain Res. 66, 141-149, 1999.
  37. Mitsui, S., Tsuruoka, N., Yamashiro, K., Nakazato, H., and Yamaguchi, N.; A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain.  European Journal of Biochemistry 260, 627-634, 1999.
  38. Mitsui, S., A. Ohuchi, T. Adachi-Yamada, M. Hotta, R. Tsuboi and H. Ogawa.   Structure and hair follicle-specific expression of genes encoding the rat high sulfur protein B2 family. Gene, 208, 123-129, 1998
  39. Mitsui, S., A. Ohuchi, M. Hotta, R. Tsuboi and H. Ogawa.  Genes of both growth factors and cyclin-dependent kinase inhibitors are expressed in a single human anagen hair follicle. British Journal of Dermatology, 137, 693-698,1997
  40. Mitsui, S., T. Wakasugi, S. Hanano and M. Sugiura.  Localization of a cytokinin-binding protein CBP57/S-adenosyl-L-homocysteine hydrolase in a tobacco root.  J. Plant Physiol., 150, 752-754 (1997)
  41. Ohuchi, Mitsui, S., M. Hotta, R. Tsuboi and H.  Ogawa.Involvememt of androgens in vivo and in vitro during the dorsal hair growth of castrated rat.  in Hiar Research for the Next Millenium, Elsevier, Amsterdam, 1996
  42. Mitsui, S., T. Wakasugi and M. Sugiura.  A cytokinin binding protein complex from tobacco leaves : The 57 kDa subunit has high homology to S-adenosyl-L-homocysteine hydrolase.  Plant Growth Regulation 18, 39-43, 1996
  43. Mitsui, S., T. Wakasugi and M. Sugiura.  A cDNA encoding the 57 kDa subunit of a cytokinin-binding protein complex: the subunit has high homology to S-adenosyl-L-homocysteine hydrolase.  Plant and Cell Physiology 34, 1089-1096, 1993
  44. Mitsui, S. and M. Sugiura.  Purification and properties of cytokinin-binding proteins from tobacco leaves.  Plant and Cell Physiology 34, 543-547, 1993
  45. K. Saitoh, Mitsui, S., K. Uchida and K. Ishikawa.  In vitro translation of α-amylase mRNA from dry wheat embryos.  Plant and Cell Physiology, 29, 1069-1072, 1988.


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